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Journal Club with Dr. Peter Attia | Metformin for Longevity & The Power of Belief Effects

Andrew HubermanScience
18chapters with key takeaways — read first, then watch
1

Introduction to Journal Club & Topics

0:00-3:27•3m 27sIntro
2

The Art of Dissecting Scientific Papers

6:11-8:37•2m 26sIntro
3

Metformin: History, Mechanism & Glucose Output

12:31-19:47•7m 16sTheory
4

Type 2 Diabetes: Insulin Resistance & Its Causes

19:47-26:45•6m 58sTheory
5

Peter's Personal Metformin Experiment & Geroprotection

26:45-29:37•2m 52sExperiment
6

The Banister Study (2014): Metformin's Perceived Longevity Benefits

29:37-39:49•10m 12sEvidence
7

Keys Paper (2023): Reassessing Metformin's Evidence

39:49-44:29•4m 40sEvidence
8

Interpreting Epidemiological Data & Crude Mortality Rates

44:29-51:29•7mEvidence
9

Kaplan-Meier Curves & Statistical Power in Research

51:29-1:01:18•9m 49sEvidence
10

Metformin's True Hazard Ratio & Confounding Factors

1:02:27-1:13:18•10m 51sEvidence
11

Metformin's Failure in ITP & Peter's Discontinuation

1:13:18-1:17:38•4m 20sEvidence
12

Berberine, Acarbose, & Glucose Disposal Agents

1:17:38-1:22:38•5mTheory
13

Caloric Restriction, Fasting, & Biomarkers of Aging

1:22:38-1:31:57•9m 19sTheory
14

Huberman's Method for Reading Scientific Papers

1:31:57-1:38:09•6m 12sTheory
15

Belief Effects: Beyond Placebo & Real-World Examples

1:38:09-1:45:23•7m 14sTheory
16

Nicotine's Cognitive Enhancement & Brain Pathways

1:45:23-1:51:09•5m 46sTheory
17

The Nicotine Belief Effect Experiment: Design & Findings

1:51:09-2:08:48•17m 39sExperiment
18

Implications of Dose-Dependent Belief & Nocebo Effects

2:08:48-2:21:19•12m 31sImplication

Video Details & AI Summary

Published Sep 11, 2023
Analyzed Dec 16, 2025

AI Analysis Summary

This Journal Club episode features Dr. Andrew Huberman and Dr. Peter Attia dissecting two scientific papers. Dr. Attia critically re-evaluates the evidence for Metformin's longevity benefits, presenting new data that challenges previous findings and discussing the complexities of epidemiological studies. Dr. Huberman then explores a groundbreaking paper on 'belief effects,' demonstrating how a person's expectation of a drug's dose can physiologically alter brain activation and performance, even when the actual dose is constant.

Title Accuracy Score
9/10Excellent
2.8m processing
Model:gemini-2.5-flash

Original Video

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