Spencer Skates, CEO of Amplitude, details his company's journey from initial skepticism to full embrace of AI, highlighting the challenges of reorienting a large organization. He discusses strategic moves like key hires, acquisitions, and an 'AI Week' to foster internal adoption, contrasting AI-native product development with traditional SaaS. Skates also shares insights on market opportunities, Amplitude's founding story, and the personal evolution from founder to public company CEO, emphasizing the critical role of intrinsic motivation and continuous learning.