This CS50 lecture introduces Artificial Intelligence, exploring its evolution from simple deterministic algorithms to advanced generative AI. It showcases CS50's custom AI-powered rubber duck, which guides students without directly providing answers, and delves into the mechanics of prompt engineering and chatbot creation. The talk further explains machine learning, reinforcement learning, neural networks, and Large Language Models (LLMs) like ChatGPT, highlighting their probabilistic nature, applications, and current limitations such as 'hallucinations.'